Objectives To summarise, by a systematic literature review (SLR), the evidence regarding
pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat …

Background Despite treatment according to the current management recommendations, a
significant proportion of patients with rheumatoid arthritis (RA) remain symptomatic. These …

Management of RA patients has significantly improved over the past decades. However, a
substantial proportion of patients is difficult-to-treat (D2T), remaining symptomatic after …

Objective To develop evidence-based European Alliance of Associations for Rheumatology
(EULAR) points to consider (PtCs) for the management of difficult-to-treat rheumatoid …

Objectives Treatment of difficult-to-treat (D2T) RA patients is generally based on trial-and-
error and can be challenging due to a myriad of contributing factors. We aimed to identify …

Objectives To summarise the evidence on diagnostic issues in difficult-to-treat rheumatoid
arthritis (D2T RA) informing the EULAR recommendations for the management of D2T RA …

Objectives Patients with difficult-to-treat rheumatoid arthritis (RA) remain symptomatic
despite treatment according to current European League Against Rheumatism (EULAR) …

Objectives To determine the impact of difficult-to-treat rheumatoid arthritis (D2T RA) on
(costs related to) healthcare utilization, other resource use and work productivity. Methods …

Background The new concept of difficult-to-treat rheumatoid arthritis (D2T RA) refers to RA
patients who remain symptomatic after several lines of treatment, resulting in a high patient …

Objectives Treatment non-adherence is more frequent among difficult-to-treat (D2T) than
among non-D2T RA patients. Perceptions of non-adherence may differ. We aimed to …