Vascular aging plays a central role in health problems and mortality in older people. Apart
from the impact of several classical cardiovascular risk factors on the vasculature …

Chagas disease (CD) is one of the most important neglected tropical diseases in the
American continent. Host-derived nitroxidative stress in response to Trypanosoma cruzi …

Currently, traditional and non-traditional risk factors for cardiovascular disease have been
established. The first group includes age, which constitutes one of the most important factors …

We previously identified genomic instability as a causative factor for vascular aging. In the
present study, we determined which vascular aging outcomes are due to local endothelial …

To quantify the association between maternal uric acid levels and pre-eclampsia risk in a
large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia …

Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …

Pentraxin-3 has been reported as a promising biomarker of pre-eclampsia and its severity;
however, available studies have small sample sizes, and analyses are not always adjusted …

DNA damage is an important contributor to endothelial dysfunction and age-related vascular
disease. Recently, we demonstrated in a DNA repair-deficient, prematurely aging mouse …

Multiple small studies have suggested that women with pre-eclampsia present elevated
levels of C-reactive protein (CRP) and interleukin-6 (IL-6). However, little is known regarding …

Introduction Angiogenic factors, such as placental growth factor (PlGF) and soluble Flt-1 (sFlt-
1), are key regulators of placental vascular development. Evidence from in vitro studies …