PURPOSE: To evaluate the risk factors for herpes zoster as well as the incidence and timing
of this complication in patients who were treated with immunosuppression because of active …

Objective Weight gain is a side effect of glucocorticoid (GC) use, but the natural history and
health implications of changes in weight that occur during the treatment of inflammatory …

Abstract Objective The RhoA/Rho kinase pathway plays a pivotal role in cold‐induced
vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This …

The treatment of Wegener's granulomatosis, one of the most common forms of systemic
vasculitis, has changed substantially over the past two decades. The principal aims of …

Introduction Long-term safety and efficacy of upadacitinib in patients with active ankylosing
spondylitis (AS) has not been previously reported. Methods In SELECT-AXIS 1, patients …

A previously healthy 45-year-old African-American man presented to the hospital with a 1-
week history of malaise, fatigue, anorexia, fever, and rigors. He reported temperatures …

Drug discovery and development is an expensive and risky endeavor. It is estimated that
only 10–15% of therapeutic compounds that enter clinical development ever reach the …

Our patient was a 59-year-old Caucasian man who had been in good health until 4 months
prior to presentation. Then, he developed daily high fevers, drenching night sweats, malaise …

Giant cell arteritis (GCA) is a major cause of vision loss and other health problems. Classic
histopathological findings include transmural inflammation with mononuclear cells and …

Raynaud's phenomenon (RP) is seen in over 95% of patients with SSc and is often the first
symptom of the disease. Scleroderma vascular disease is secondary to an obliterative …