User profiles for "author:Samuel Bitoun"

Samuel Bitoun

Rheumatology departement, Bicêtre Hospital, Paris Saclay University
Verified email at aphp.fr
Cited by 412

Rituximab impairs B cell response but not T cell response to COVID‐19 vaccine in autoimmune diseases

S Bitoun, J Henry, D Desjardins… - Arthritis & …, 2022 - Wiley Online Library
Objective Antibody response to the messenger RNA (mRNA) COVID‐19 vaccine has been
shown to be diminished in rituximab (RTX)–treated patients. We undertook this study to …

[PDF][PDF] Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease

DE Matei, M Menon, DG Alber, AM Smith… - Med, 2021 - cell.com
Background Evidence suggests an important role for gut-microbiota dysbiosis in the
development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the …

Treatment of neurosarcoidosis: a comparative study of methotrexate and mycophenolate mofetil

S Bitoun, D Bouvry, R Borie, M Mahevas, K Sacre… - Neurology, 2016 - AAN Enterprises
Objective: To compare the efficacy of methotrexate (MTX) and mycophenolate mofetil (MMF)
in the prevention of relapses in neurosarcoidosis. Methods: We conducted a retrospective …

Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis

R Kireev, S Bitoun, S Cuesta, A Tejerina… - European Journal of …, 2013 - Elsevier
Fatty livers occur in up to 20% of potential liver donors and increase cellular injury during the
ischemia/reperfusion phase, so any intervention that could enable a better outcome of grafts …

[HTML][HTML] Response to COVID-19 mRNA vaccination in multiple myeloma is conserved but impaired compared to controls

S Bitoun, J Henry, C Vauloup-Fellous, N Dib… - Journal of Hematology & …, 2021 - Springer
Patients with multiple myeloma are at high risk of severe forms of COVID-19. Despite data
showing diminished response to vaccine, the era of highly efficient mRNA vaccine might be …

Methotrexate and BAFF interaction prevents immunization against TNF inhibitors

S Bitoun, G Nocturne, B Ly, R Krzysiek… - Annals of the …, 2018 - ard.bmj.com
Objectives TNF inhibitors (TNFi) can induce anti-drug antibodies (ADA) in patients with
autoimmune diseases (AID) leading to clinical resistance. We explored a new way of using …

Response to biologic drugs in patients with rheumatoid arthritis and antidrug antibodies

S Bitoun, S Hässler, D Ternant, N Szely… - JAMA Network …, 2023 - jamanetwork.com
Importance There are conflicting data on the association of antidrug antibodies with
response to biologic disease–modifying antirheumatic drugs (bDMARDs) in rheumatoid …

[HTML][HTML] Characterization of phenotypes and functional activities of leukocytes from rheumatoid arthritis patients by mass cytometry

A Leite Pereira, S Bitoun, A Paoletti… - Frontiers in …, 2019 - frontiersin.org
Background: Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease
and leads to persistent chronic inflammation. The pathophysiology of the disease is …

[HTML][HTML] Pegylation reduces the uptake of certolizumab pegol by dendritic cells and epitope presentation to T-cells

M de Bourayne, S Meunier, S Bitoun, E Correia… - Frontiers in …, 2022 - frontiersin.org
Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in
the blood and is associated with a reduced immunogenicity. As antigen presentation is a …

Prophylaxis with tixagevimab/cilgavimab is associated with lower COVID-19 incidence and severity in patients with autoimmune diseases

M Thomas, M Masson, S Bitoun, S Hamroun… - …, 2023 - academic.oup.com
Objective To describe the clinical efficacy of tixagevimab/cilgavimab in pre-exposure
prophylaxis in patients at risk of severe coronavirus disease 2019 (COVID-19) and …