In this Review we describe three approaches for cartilage tissue repair at the rheumatology–
orthopaedics interface: disease-modifying osteoarthritis (OA) drug (DMOAD) treatment; cell …

Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of
articular cartilage, subchondral bone sclerosis, osteophyte formation, and synovial …

Background Modification of joint tissue damage is challenging in late-stage osteoarthritis
(OA). Few options are available for treating end-stage knee OA other than joint replacement …

Background This study evaluates changes in peri-articular bone in two canine models for
osteoarthritis: the groove model and the anterior cruciate ligament transection (ACLT) …

Abstract Treatment of osteoarthritis (OA) with nonsteroidal anti-inflammatory drugs (NSAIDs)
diminishes inflammation along with mediators of cartilage destruction. However, NSAIDs …

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …

Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Objective In end-stage knee osteoarthritis, total knee arthroplasty (TKA) may finally become
inevitable. At a relatively young age, this comes with the risk of future revision surgery …

Objectives Knee joint distraction (KJD) is a novel, but poorly understood, treatment for
osteoarthritis (OA) associated with remarkable 'spontaneous' cartilage repair in which …