Background Increases in lipid levels and cancers with tofacitinib prompted a trial of major
adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis …

Background Cyclophosphamide and glucocorticoids have been the cornerstone of
remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA) …

Background Published small case series suggest that inflammatory bowel disease [IBD;
Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than …

Objective To develop and validate new classification criteria for adult and juvenile idiopathic
inflammatory myopathies (IIM) and their major subgroups. Methods Candidate variables …

Background The 18-month efficacy of a single course of rituximab as compared with
conventional immunosuppression with cyclophosphamide followed by azathioprine in …

Rationale: Standard therapy for Wegener's granulomatosis is fraught with substantial toxicity
and not always effective. B lymphocytes have been implicated in the pathogenesis of …

Levels of interferon (IFN) were measured in 81 serum samples from 23 patients with
systemic lupus erythematosus (SLE) by a plaque‐reduction method and correlated …

Objective This study was conducted to evaluate the efficacy and safety of repeated and
prolonged B cell depletion with rituximab (RTX) for the maintenance of long‐term remission …

BACKGROUND: The pathogenic significance of antineutrophilic cytoplasmic antibodies
(ANCA) in Wegener's granulomatosis is controversial. Their presence is influenced by the …

Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant
cell arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or …