Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying …

T Takeuchi, Y Tanaka, S Soen, H Yamanaka… - Annals of the …, 2019 - ard.bmj.com
Objective To evaluate the efficacy of denosumab in suppressing joint destruction when
added to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy …

Predictors of new bone erosion in rheumatoid arthritis patients receiving conventional synthetic disease-modifying antirheumatic drugs: analysis of data from the …

T Takeuchi, S Soen, N Ishiguro… - Modern …, 2021 - academic.oup.com
Objective To investigate new bone erosion and cartilage destruction predictors in
rheumatoid arthritis (RA) patients treated with conventional synthetic disease-modifying …

Effects of denosumab in Japanese patients with rheumatoid arthritis treated with conventional antirheumatic drugs: 36-month extension of a phase III study

Y Tanaka, T Takeuchi, S Soen, H Yamanaka… - The Journal of …, 2021 - jrheum.org
Objective To evaluate the safety and efficacy of long-term denosumab 60 mg every 6 months
(Q6M) or every 3 months (Q3M) in patients with rheumatoid arthritis (RA). Methods This 12 …

Glucocorticoid-induced secondary osteopenia in female rats: a time course study as compared with ovariectomy-induced osteopenia and response to salmon …

T Nitta, T Fukushima, H Nakamuta… - The Japanese Journal of …, 1999 - jstage.jst.go.jp
抄録 Previously we reported that 8-week treatment with methylprednisolone acetate (MPA:
0.1 mg/kg, sc, 3 days a week) of male rats caused a novel type of osteopenia whose …

Identifying the preferable rheumatoid arthritis subgroups for intervention with the anti-RANKL antibody denosumab to reduce progression of joint destruction

Y Tanaka, S Soen, N Ishiguro, H Yamanaka… - RMD open, 2020 - rmdopen.bmj.com
Objectives To clarify which rheumatoid arthritis (RA) patients benefit most from the anti-
receptor activator of nuclear factor-κB ligand antibody denosumab to reduce the progression …

Glucocorticoid-induced osteopenia in rats: histomorphometrical and microarchitectural characterization and calcitonin effect

H NAKAMUTA, T NITTA, T HOSHINO… - Biological and …, 1996 - jstage.jst.go.jp
抄録 A glucocorticoid-induced osteopenia (GC-OP) model was developed in Wistar male
rats to use for in vivo screening of anti-osteoporotic candidates. 1) Two week treatment with …

Bone anabolic effects of PTH (1-34) and salmon calcitonin in ovariectomy-and ovariectomy-steroid-induced osteopenic rats: a histomorphometric and biomechanical …

T Fukushima, T Nitta, H Furuichi, N Izumo… - The Japanese Journal …, 2000 - jstage.jst.go.jp
抄録 Using an experimental model of type 1 osteoporosis under the chronic therapy with an
anti-inflammatory steroid, the bone anabolic effect of PTH (1-34) was evaluated by …

Histomorphometrical evaluation of anti-osteopenic effect of nasal salmon calcitonin in a type 1 osteoporotic model of rats

T NITTA, T HOSHINO, M KOIDA… - Biological and …, 1996 - jstage.jst.go.jp
It was examined histomorphometrically whether or not and how chronic treatment with nasal
salmon calcitonin (SCT) of rats could prevent ovariectomy (OVX)-induced osteoporotic …

Glucocorticoid-Induced Osteopenia in Rats: Histomorphometrical and Microarchitectural Characterization and Calcitonin Effect.

N Hiromichi, N Takaya, H Takashi… - … & Pharmaceutical Bulletin, 1996 - cir.nii.ac.jp
抄録 A glucocorticoid-induced osteopenia (GC-OP) model was developed in Wistar male
rats to use for in vivo screening of anti-osteoporotic candidates. 1) Two week treatment with …

Effects of denosumab in Japanese rheumatoid arthritis patients treated with conventional anti-rheumatic drugs: 36-month extension of a phase 3 study

Y Tanaka, T Takeuchi, S Soen, H Yamanaka… - The Journal of …, 2021 - jrheum.org
Objective To evaluate safety and efficacy of long-term denosumab 60 mg every 6 (Q6M) or 3
months (Q3M) in rheumatoid arthritis (RA) patients. Methods This 12-month, randomised …