User profiles for "author:Xiaodong Wang"

Xiaodong Wang

National Institute of Biological Sciences
Verified email at nibs.ac.cn
Cited by 90846

Biochemical pathways of caspase activation during apoptosis

I Budihardjo, H Oliver, M Lutter, X Luo… - Annual review of cell …, 1999 - annualreviews.org
▪ Abstract Caspase activation plays a central role in the execution of apoptosis. The key
components of the biochemical pathways of caspase activation have been recently …

The expanding role of mitochondria in apoptosis

X Wang - Genes & development, 2001 - genesdev.cshlp.org
The initial insight into the genetic basis of apoptosis, or programmed cell death, was gained
from ingenious studies of the roundworm Caenorhabditis elegans (for review, see Horvitz …

Cytochrome C-Mediated Apoptosis

X Jiang, X Wang - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract Apoptosis, or programmed cell death, is involved in development, elimination of
damaged cells, and maintenance of cell homeostasis. Deregulation of apoptosis may cause …

[HTML][HTML] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

P Li, D Nijhawan, I Budihardjo, SM Srinivasula… - cell, 1997 - cell.com
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-
3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9 …

[HTML][HTML] Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

X Liu, CN Kim, J Yang, R Jemmerson, X Wang - Cell, 1996 - cell.com
A cell-free system based on cytosols of normally growing cells is established that
reproduces aspects of the apoptotic program in vitro. The apoptotic program is initiated by …

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

J Yang, X Liu, K Bhalla, CN Kim, AM Ibrado, J Cai… - Science, 1997 - science.org
Bcl-2 is an integral membrane protein located mainly on the outer membrane of
mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in …

[HTML][HTML] Smac, a mitochondrial protein that promotes cytochrome c–dependent caspase activation by eliminating IAP inhibition

C Du, M Fang, Y Li, L Li, X Wang - Cell, 2000 - cell.com
We report here the identification of a novel protein, Smac, which promotes caspase
activation in the cytochrome c/Apaf-1/caspase-9 pathway. Smac promotes caspase-9 …

[HTML][HTML] Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

X Luo, I Budihardjo, H Zou, C Slaughter, X Wang - Cell, 1998 - cell.com
We report here the purification of a cytosolic protein that induces cytochrome c release from
mitochondria in response to caspase-8, the apical caspase activated by cell surface death …

[HTML][HTML] Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3

H Zou, WJ Henzel, X Liu, A Lutschg, X Wang - Cell, 1997 - cell.com
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from
HeLa cell cytosol that participates in the cytochrome c–dependent activation of caspase-3 …

[HTML][HTML] An APAF-1· cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

H Zou, Y Li, X Liu, X Wang - Journal of Biological Chemistry, 1999 - ASBMB
We report here the reconstitution of the de novo procaspase-9 activation pathway using
highly purified cytochrome c, recombinant APAF-1, and recombinant procaspase-9. APAF-1 …