Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Objectives To provide an update of the European League Against Rheumatism (EULAR)
rheumatoid arthritis (RA) management recommendations to account for the most recent …

Background The efficacy of arthroscopic surgery for the treatment of osteoarthritis of the
knee is unknown. Methods We conducted a single-center, randomized, controlled trial of …

Objective Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death
in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to …

New treatment strategies have substantially changed the course of rheumatoid arthritis. Many
patients can achieve remission if the disease is recognised early and is treated promptly …

Background and Methods Osteoporosis is a recognized complication of corticosteroid
therapy. Whether it can be prevented is not known. We conducted a 12-month, randomized, …

Background A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic
sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung …

Objective Early diffuse scleroderma (systemic sclerosis; SSc) has no proven treatment. This
study was undertaken to examine the efficacy of methotrexate (MTX) in improving the skin …

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have well-known gastrointestinal
and renal toxic reactions. Effects of NSAIDs on blood pressure are less appreciated. A …

Objective. The 1980 American College of Rheuma-tology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …