Background Cyclophosphamide and glucocorticoids have been the cornerstone of
remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)−associated …

CD4 + T cells can eliminate tumor cells in vivo in the absence of CD8 + T cells. We have CD4
+ T cells specific for a MHC class II-restricted, tumor-specific peptide derived from a mutant …

Background The 18-month efficacy of a single course of rituximab as compared with conventional
immunosuppression with cyclophosphamide followed by azathioprine in patients with …

Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-…

Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant cell
arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or relapsing …

Mice immunized against a cancer recognize antigens unique to that cancer, but the molecular
structures of such antigens are unknown. We isolated CD4+ T ceil clones recognizing an …

Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic
antibody (ANCA)-associated vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3…

Objectives To compare patterns of arteriographic lesions of the aorta and primary branches
in patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA). Methods Patients …

Mice expressing both the T cell receptor (TCR) transgene KRN and the MHC class II molecule
A g7 (K/BxN mice) develop severe inflammatory arthritis, and serum from these mice …

Objective To identify genetic determinants of granulomatosis with polyangiitis (Wegener's) (GPA).
Methods We carried out a genome‐wide association study (GWAS) of 492 GPA cases …