Background Autoinflammatory diseases manifest inflammation without evidence of infection,
high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations …

Background Systemic juvenile idiopathic arthritis (JIA) is the most severe subtype of JIA;
treatment options are limited. Interleukin-6 plays a pathogenic role in systemic JIA. Methods We …

Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process, …

Background Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis
(JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti–…

Purpose Genetic testing is an integral diagnostic component of pediatric medicine. Standard
of care is often a time-consuming stepwise approach involving chromosomal microarray …

Objective To develop treatment recommendations for children with juvenile idiopathic arthritis
manifesting as non‐systemic polyarthritis, sacroiliitis, or enthesitis. Methods The Patient/…

Objective To evaluate the long‐term efficacy and safety of etanercept in children with juvenile
rheumatoid arthritis (JRA) participating in an ongoing multicenter, open‐label, extended‐…

… Schneider has received consulting fees from Novartis and Sobi (less than $10,000 each).
No other disclosures relevant to this article were reported. Address correspondence to Sheila T…

Objective Primary angiitis of the central nervous system (PACNS) is a severe and ill‐defined
neurologic disease. The goal of this study was to characterize the presenting features, …

Objective To describe clinical outcomes of juvenile idiopathic arthritis (JIA) in a prospective
inception cohort of children managed with contemporary treatments. Methods Children newly …