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Osteoarthritis
Original article
Cardiometabolic risk factors in primary centred and rotator cuff-related shoulder osteoarthritis: a comparative study
  1. Pierre-Antoine Juge1,
  2. Laure Berard2,
  3. Salma Kotti3,
  4. Levon Doursounian4,
  5. Alain Sautet4,
  6. Tabassome Simon3,
  7. Francis Berenbaum1,
  8. Geoffroy Nourissat4,5 and
  9. Jérémie Sellam1
  10. Rhumatologique français de l'Epaule (GREP)
  1. 1Rheumatology Department, Saint-Antoine hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Univ Paris 06, Inserm UMRS_938, DHU i2B, Paris, France
  2. 2Rheumatology Department, Le Havre Hospital, Le Havre, France
  3. 3Unité de Recherche Clinique de l’Est Parisien, AP-HP, Saint-Antoine hospital, Paris, France
  4. 4Orthopedic surgery department, AP-HP Saint-Antoine hospital, Univ Paris 06, Paris, France
  5. 5Clinique des Maussins-Nollet, Paris, France
  1. Correspondence to Professor Francis Berenbaum; francis.berenbaum{at}aphp.fr

Abstract

Background Risk factors for shoulder osteoarthritis (SOA) have been poorly studied. SOA has two anatomical subtypes: primary centred SOA (centred SOA) and rotator cuff-related OA (non-centred SOA). We examined whether cardiometabolic risk factors are preferentially associated with centred than mechanical-induced non-centred SOA.

Methods This 2004–2012 retrospective multicentric study included patients with SOA. Data on clinical characteristics, especially cardiometabolic risk factors, were collected. We compared patients with radiographic-centred and non-centred SOA and tested the association between cardiometabolic risk factors and subtypes of SOA.

Results We included 147 patients (101 women (68.7%); mean age 75.8±10 years); 99 had centred SOA. As compared with patients with non-centred SOA, those with centred SOA were older (77.5±9 vs 72.4±11 years; p=0.004) with no difference in cardiometabolic disturbances or their accumulation. Multivariable analyses indicated that older age was independently associated with centred SOA (OR 1.06;95% CI 1.02 to 1.1; p=0.004), and cardiovascular diseases were less associated with this subtype (OR 0.27; 95% CI 0.089 to 0.824; p=0.02) than with the non-centred one.

Conclusion Cardiometabolic risk factors were not more prevalent with primary centred than rotator cuff-related SOA. They may participate in the pathophysiology of both SOA subtypes through cartilage and tendon disruption.

  • Osteoarthritis
  • Cardiovascular Disease
  • Arterial Hypertension
  • Lipids

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/rmdopen-2016-000429

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    Footnotes

    • Contributors JS, LB, GN, FB and P-AJ contributed to study conception, data acquisition, data analysis and interpretation. SK and TS contributed to statistical analysis. FB, LD and AS contributed to data analysis and interpretation. All the authors reviewed the manuscript.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Comité de Protection des Personnes + Commission Nationale de l'Informatique et des Libertés.

    • Provenance and peer review Not commissioned; externally peer reviewed.