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Key messages
What is already known about this subject?
BAFF/BLyS is a key cytokine in systemic lupus erythematosus (SLE) and targeting BAFF by belimumab is used to treat patients with SLE.
Antiphospholipid syndrome (APS) is a major cause of thrombosis and pregnancy morbidity in patients with rheumatic diseases and immunomodulatory treatments are novel drug candidates to treat APS.
What does this study add?
BAFF levels are elevated in patient with primary APS and correlate with higher adjusted global antiphospholipid syndrome scores.
In SLE, but not in APS, the expression of BAFF receptors is altered on peripheral blood B cells.
How might this impact on clinical practice?
A subset of patients with APS may benefit from BAFF- targeting therapies such as belimumab.
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by antiphospholipid antibodies (aPL), thrombosis and obstetric complications. Other manifestations seen in APS include thrombocytopenia, heart valve disease and leg ulcers. APS was first described in patients suffering from systemic lupus erythematosus (SLE). However, APS may also affect patients not suffering from SLE or another underlying disease, termed primary APS (PAPS). Current treatment strategies for APS relying on anticoagulants are suboptimal, particularly for non-thrombotic manifestations and immunomodulatory drugs have been suggested as potential novel drug candidates in APS.1 2
B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), is an important growth factor for B cells. The importance of BAFF in SLE is supported by animal models as mice transgenic for BAFF spontaneously develop SLE-like autoimmunity including the production of antibodies against double-stranded DNA (anti-dsDNA).3 In …